Brian T. Faddis, PhD

Assistant Professor of Otolaryngology
Director, Research Center for Auditory & Vestibular Studies

Faddis Lab Website
RCAVS
http://pacs.wustl.edu/

Mailing Address:

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110

Research Interests: Our lab is interested in the cellular and molecular mechanisms underlying tissue damage in both peripheral and central auditory structures. We focus on molecules that have roles in normal audition as well as tissue destruction due to inflammation, noise exposure and aging. We are currently studying the roles of two small families of molecules, the nitric oxide synthase proteins and the synuclein proteins. Our goal is to relate changes in auditory sensitivity to cellular damage and alterations in the expression of these proteins. For more information visit Dr. Faddis' Lab


Education

  • BS (Psychology)—UC Davis
  • MS (Human Anatomy)—UC Davis
  • PhD (Comparative Pathology)—UC Davis

Selected Publications

  1. Faddis BT, Hasbani MJ and Goldberg MP (1997) Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J. Neurosci., 17(3):951-959.

  2. Faddis BT and McGinn MD (1997) Spongiform degeneration of the gerbil cochlear nucleus: An ultrastructural and immunohistochemical evaluation. J. Neurocytol., 26 (9):625-635.

  3. Chole, RA and Faddis BT (2002) Evidence for microbial biofilms in cholesteatomas. Arch. Otolaryngol. Head Neck Surg., 128:1129-1133.

  4. Jung JY, Lin AC, Ramos LM, Faddis BT and Chole RA (2003) Nitric oxide synthase I mediates osteoclast activity in vitro and in vivo. J. Cell. Biochem., 89:613-621.

  5. Tekkok, SB, Faddis BT and Goldberg MP (2005) AMPA/kainate receptors mediate axonal morphological disruption in hypoxic white matter. Neurosci. Lett., 382:275-9.

  6. Dorsey DA, Masco D, Dikranian K, Hyrc K, Masciotra L, Faddis BT, Soriano M, Gru AA, Goldberg MP and de Erasquin GA. (2006) Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons. Apoptosis, 11:533-544.