Jeffery T. Lichtenhan, PhD

Assistant Professor of Otolaryngology

Lichtenhan Lab Website

Mailing Address:

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110

Research Interests: Our research addresses questions related to normal and diseased cochlear physiology. We aim to understand the origins of objective measurements that can be used in the both the clinic and laboratory. Greater understanding of the cell types, spatial location, and contributing mechanisms of hearing loss will lead to improved differential diagnostic capabilities. Improved diagnostic ability is essential to realizing the promising advances being made in inner ear regenerative medicine.


Education

  • Postdoctoral Fellowship in Auditory Physiology, Harvard Medical School (2007-2011)
  • Ph.D. Audiology, University of Kansas (2006)
  • M.A. Audiology, University of Kansas Medical Center (2002)

Selected Publications

  1. Lichtenhan, J.T., Lee, C., Wenrich, K.A., Dubaybo, F. Wilson, U.S. (2017). “The Auditory Nerve Overlapped Waveform (ANOW) detects small endolymphatic manipulations that may go undetected by conventional measurements” Frontiers in Neuroscience. 11:405.

  2. Wilson, U.S., Sadler, K.M., Hancock, K.E., Guinan, J.J. Jr., Lichtenhan, J.T. (2017). “Efferent inhibition strength is a Physiological Correlate of Hyperacusis in Children with Autism Spectrum Disorder” Journal of Neurophysiology. 118(2):1164-1172.

  3. Lichtenhan, J.T., Hirose, K., Buchman, C.A., Duncan, R.K. Salt, A.N. (2017). “Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements” PLoS One. 12(4):e0175236.

  4. Lichtenhan, J.T., Hartsock, J.J., Dornhoffer, J., Donovan, K.M., Salt, A.N. (2016). “Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral” Journal of Neuroscience Methods.1;273:201-209.

  5. Lichtenhan, J.T., Wilson, U.S., Hancock, K.E., Guinan, J.J. (2016). “Medial Olivocochlear Efferent Reflex Inhibition of Human Cochlear Nerve Responses” Hearing Research. 333:216-24.

  6. Lichtenhan, J.T., Hartsock, J.J., Gill, R.M., Guinan, J.J., Salt, A.N. (2014). “The Auditory Nerve Overlapped Waveform (ANOW) Originates in the Cochlear Apex” Journal of the Association for Research in Otolaryngology. 15(3):395-411.

  7. Salt, A.N, Lichtenhan, J.T., Gill, R.M., Hartsock, J.J. (2013). “Large endolymphatic potentials from low-frequency and infrasonic tones in the guinea pig” Journal of the Acoustical Society of America. 133(3), 1561-1571.

  8. Lichtenhan, J.T., Cooper, N.P. and Guinan, J.J. (2013). “A new auditory threshold estimation technique for low frequencies: Proof of concept” Ear & Hearing, 34(1):42-51.

  9. Lichtenhan, J. T. (2012). Effects of Low-Frequency Biasing on Otoacoustic and Neural Measures Suggest that Stimulus-Frequency Otoacoustic Emissions Originate Near the Peak Region of the Traveling Wave. Journal of the Association for Research in Otolaryngology, 13, 17-28.

  10. Chertoff, M.E., Lichtenhan, J.T., and Willis, M. (2010). “Click-and chirp-evoked human compound action potentials.” Journal of the Acoustical Society of America. 127(5), 2992-2996.

  11. Lichtenhan, J.T. and Chertoff, M.E. (2008). “Temporary hearing loss influences poststimulus time histogram and single neuron action potential estimates from human compound action potentials.” Journal of the Acoustical Society of America. 123(4), 2200-2212.

  12. Lichtenhan, J.T., Chertoff, M.E., Smittkamp, S., Durham, D. and Girod, D (2005). “Predicting severity of cochlear hair cell damage using DPOAE input-output functions,” Hearing Research. 201, 109-120.

  13. Chertoff, M.E., Yi, X and Lichtenhan, J.T. (2003). “Influence of hearing sensitivity on mechano-electric transduction.” Journal of the Acoustical Society of America. 114(6), 3251-3263.