Jeffery T. Lichtenhan, PhD

Assistant Professor of Otolaryngology

Lichtenhan Lab Website

Mailing Address:

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110

Research Interests: Our research addresses questions on normal and pathologic cochlear physiology. Our approach requires the development of novel electrophysiologic techniques. At present, we are using a new objective measure of low-frequency physiology. As compared to the cochlear base, less is known about the cochlear apex because, in part, conventional electrophysiologic techniques such as otoacoustic emissions and compound action potentials perform adequately only at high-frequencies above 1 kHz or so. Understanding low-frequency hearing and hearing loss is important because speech vowels and many bothersome environmental background noises are of low frequency. Adjunct to our research is exploring the possibility that our novel techniques can be used to improve differential diagnostics for sensorineural hearing loss. Currently available diagnostic tests cannot determine if hearing loss in individual ears is caused by, for example, damage to stria vascularis cells, hair cell sterocilia or tip links, outer hair cell bodies, or the high- or low-spontaneous rate afferent fibers of the inner hair cells. Improved differential diagnostics are critical to identify specific targets for the promising future inner ear regenerative medicine.


Education

  • Postdoctoral Fellowship in Auditory Physiology, Harvard Medical School (2007-2011)
  • Ph.D. Audiology, University of Kansas (2006)
  • M.A. Audiology, University of Kansas Medical Center (2002)

Selected Publications

  1. Lichtenhan, J.T., Cooper, N.P. and Guinan, J.J. (In Press). “A new auditory threshold estimation technique for low frequencies: Proof of concept” Ear & Hearing.

  2. Salt, A.N. and Lichtenhan, J.T. (2012). “Perception-based protection from low-frequency sounds may not be enough” Proceedings of the Fourth International INTER-NOISE, the 41st International Congress and Exposition on Noise Control Engineering, New York, New York. August 19-21.

  3. Lichtenhan, J. T. (2012). Effects of Low-Frequency Biasing on Otoacoustic and Neural Measures Suggest that Stimulus-Frequency Otoacoustic Emissions Originate Near the Peak Region of the Traveling Wave. J Assoc Res Otolaryngol, 13, 17-28.

  4. Lichtenhan, J.T., Brown, D.J., McLean, W.J., Chertoff, M.E., and Salt, A.N. (2011). A source of cochlear distortion and its utility for differential diagnosis of sensorineural hearing loss. Audiology Today, Nov/Dec.

  5. Salt, A.N. and Lichtenhan, J.T. (2011). “Responses of the Inner Ear to Infrasound.” Proceedings of the Fourth International Meeting on Wind Turbine Noise. Rome, Italy. April 12-14.

  6. Chertoff, M.E., Lichtenhan, J.T., and Willis, M. (2010). “Click-and chirp-evoked human compound action potentials.” Journal of the Acoustical Society of America. 127(5), 2992-2996.

  7. Chertoff, M.E., Lichtenhan, J.T., Tourtillott, B. and Esau, K.S. (2008). “The influence of noise exposure on the parameters of a convolution model of the compound action potential.” Journal of the Acoustical Society of America. 124(4), 2174-2185.

  8. Lichtenhan, J.T. and Chertoff, M.E. (2008). “Temporary hearing loss influences poststimulus time histogram and single neuron action potential estimates from human compound action potentials.” Journal of the Acoustical Society of America. 123(4), 2200-2212.

  9. Lichtenhan, J.T., Chertoff, M.E., Smittkamp, S., Durham, D. and Girod, D (2005). “Predicting severity of cochlear hair cell damage using DPOAE input-output functions,” Hearing Research. 201, 109-120.

  10. Chertoff, M.E., Yi, X and Lichtenhan, J.T. (2003). “Influence of hearing sensitivity on mechano-electric transduction.” Journal of the Acoustical Society of America. 114(6), 3251-3263.