Keiko Hirose, MD

Professor, Director, Pediatric Division Otolaryngology-Head and Neck Surgery

WU Physicians Bio
Hirose Lab Website

Pediatric hearing loss, cochlear implantation, chronic ear surgery, cholesteatoma, conductive hearing loss, aural atresia, BAHA, ear infections, speech disorders, velopharyngeal insufficiency, cleft palate, craniofacial disorders.

Patients Seen At:


Mailing Address:

St. Louis Children's Hospital
One Children's Place
Third Floor
St. Louis, MO 63110

Children’s Specialty Care Center
13001 North Outer Forty
Town & Country, MO 63017
Floor 2, Suite D

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110


  • B.A., Columbia College, Columbia University, New York, 1989
  • M.D., Harvard Medical School, Boston, MA 1993
  • Internship, University of Washington Medical Center, Seattle, WA 1994
  • Residency, University of Washington Medical Center, Seattle, WA 1999
  • Fellowship, Children's Hospital of Boston, Boston, MA 2000

Licensure and Board Certification

  • Otolaryngology-Certified


  • George Adams Young Faculty Triologic Society Award, 2007
  • Resident Travel Award, Combined Otolaryngology Spring Meeting, 1999
  • Resident Travel Award, Western Sectional Meeting of the Triologic Society, 1998 Best Doctors in America, 2006, 2007
  • Cleveland Top Doctors, 2006, 2007

Selected Publications

  1. Cheng HM, Hirose K, Xiong H, Gonzalez RG. Polyol pathway activity in streptozotocin-diabetic rat lens. Experimental Eye Research. 1989;49:87-92.

  2. Cheng HM, Hirose K, Xiong H. Generation of alpha-L-glycerophosphate in the lens. Experimental Eye Research. 1989;49:281-5.

  3. Hirose K, Chan PH. Blockade of glutamate excitotoxicity and its clinical applications. Neurochemical Research. 1993;18:479-83.

  4. Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hearing Research. 1997;104:1-14.

  5. Hirose K, Wener M, Duckert LG. Utility of laboratory testing in autoimmune sensorineural hearing loss. Laryngoscope. 1999;109;11:1749-54.

  6. Hirose K, Westrum LE, Stone JS, Zirpel L, Rubel EW. Dynamic studies of ototoxicity of mature avian auditory epithelium. Annals of the New York Academy of Sciences. 1999;884:389-409.

  7. Wang Y, Hirose K, and Liberman MC. Dynamics of noise induced cellular injury and repair in the mouse cochlea. Journal of the Association for Research in Otolaryngology. 2002;03:248-268.

  8. Hirose K. and Liberman MC. Lateral wall histopathology and endocochlear potential in the noise damaged mouse cochlea. Journal of the Association for Research in Otolaryngology. 2003;04:339-352.

  9. Discolo C and Hirose K. Pediatric Cochlear Implants. American Journal of Audiology, 2003;11:114-118.

  10. Koltai PJ, Solares CA, Koempel JA, Chan J, Hirose K, Abelson TI, Krakovitz PR, Xu M, Mascha EJ: Intracapsular Tonsillar Reduction (Partial Tonsillectomy): Reviewing a Historical Procedure for Obstructive Sleep Disordered Breathing in Children. Otolaryngol Head Neck Surg, 2003;129:532-538.

  11. Hirose K, Cunningham DE, Westrum LE, Rubel EW. Electron microscopy of the early changes in hair cell degeneration after exposure to gentamicin in vivo. Journal of Comparative Neurology, 2004; 40: 164-180.

  12. Solares CA, Edling AE, Hirose K, Hughes GB, Tuohy VK. Experimental autoimmune hearing loss mediated by CD4+ T cells specific for mouse inner ear peptides. Journal of Clinical Investigation. 2004;113:1210-1227.

  13. Solares CA, Krakovitz P, Hirose K, Koltai PJ. Starplasty: revisiting a pediatric tracheostomy technique. Otolaryngol Head Neck Surg. 2004;131(5):717-22.

  14. Hildebrand MS, de Silva MG, Klockars T, Solares CA, Hirose K, Smith JD, Patel, SC, Dahl HHM. Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hearing Research, 2005;200:102-114.

  15. Hirose K, Discolo C, Keasler J, Ransohoff R. Mononuclear Phagocytes Migrate into theMurine Cochlea after Acoustic Trauma. Journal of Comparative Neurology, 2005;489:180-194.

  16. Cannady S, Hirose K, Koltai PJ. Surgical Management of Cervical Ganglioneuromas in Children. International Journal of Pediatric Otorhinolaryngology, 2006;70(2):287-94.

  17. Rowe T, Rizzi M, Hirose K, Peters G, Sen GC. Novel role of the double stranded RNA-binding protein, PACT in mouse ear development and hearing. Proceedings of the National Academy of Sciences, 2006:103(15):5823-8.

  18. Sautter NB, Shick HE, Ransohoff RM, Charo IF, Hirose K. CC chemokine receptor 2 (CCR2) is protective against noise-induced hair cell death. Journal of the Association for Research in Otolaryngology. 2006: 7(4):361-72.

  19. Gao J, Maison SF, Wu X, Hirose K, Jones, SM, Bayazitov I, Tian Y, Mittleman G, Matthews D, Zakharenko S, Liberman MC, Zuo J. The orphan glutamate receptor delta1 subunit is required for high-frequency hearing, Molecular and Cellular Biology. 2007;27(12):4500-4512.

  20. Sato E, Shick HE, Ransohoff RM, Hirose K*. Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1. Journal of Comparative Neurology. 2008;506(6):930-942.

  21. Sato E, Shick HE, Ransohoff RM, Hirose K*. Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury. Journal of the Association for Research in Otolaryngology. 2010: 11(2):223-34.

  22. Hirose K and Sato E. Comparative analysis of the effects of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea. Hearing Research. 2011: 272(1-2):108-16.

  23. Warchol ME, Schwendener RA, Hirose K. Depletion of resident macrophages does not alter sensory regeneration in the avian cochlea. 2012 Plos ONE 7(12): e51574. Doi:10.1371/journal.pone.0051574.

  24. Slattery E, White A, Hirose K. Tolosa-Hunt syndrome masquerading as Gradenigo syndrome in a teenager International Journal of Pediatric Otorhinolaryngology – in press.

Invited Publications

  1. Rizzi M and Hirose K. Aminoglycoside Ototoxicity. In: Current opinions in Otolaryngology and Head and Neck Surgery. 2007;15(5):352-257.

Books, Chapters Published or in Press

  1. Kenna MA and Hirose K. Embryology and developmental anatomy of the ear. In: Bluestone, C.D., Stool, S.E., Alper C.M., et al., eds. Pediatric Otolaryngology. 4th ed. Philadelphia: Saunders. 2003.

  2. Rizzi M and Hirose K. Aminoglycoside Ototoxicity. In: Ototoxicity for Audiologists. In press.

  3. Sautter NB and Hirose K. Otitis Media. In: Hughes GB and Pensak ML, eds. Clinic Otology. 3rd ed. New York, Thieme. In press.