Tatyana A. Yakusheva, PhD

Assistant Professor of Otolaryngology

Yakusheva Lab Website

Mailing Address:

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110

My work focuses on understanding the role of the cerebellar nodulus and uvula (NU) in motion perception and spatial navigation. We aim to understand how NU processes the vestibular signals arriving directly or indirectly from the vestibular organs (otolith and semicircular canal afferents). Specifically, we study the role of NU inhibitory interneurons in vestibular signal transformation. Our recent work has shown that NU Purkinje cells (the sole output of the cerebellar cortex) exclusively encode inertial motion (translation) by combining otolith signals with a transformed signal from the semicircular canals. It is still unknown however, whether translation is computed within the NU or it is sent there already computed by its inputs, e.g. the vestibular nuclei. To answer these questions I will evaluate the role of GABAergic interneurons within the NU in the transformation of head- centered vestibular afferent information into inertial motion. Together, these experiments will elucidate the role of inhibitory interneurons in the signal transformations carried out by the NU and have the potential of unveiling general rules of cerebellar function. Furthermore, a better understanding NU function could lead to the development of therapies for rehabilitation following disease and trauma of the vestibular organs or the cerebellar cortex. My goal is to use this understanding to aid in the development of prosthetics and other tools for treating diseases, as well as to provide guidance to molecular approaches aimed to repair lost brain function.


Education

  • Saratov State University, Saratov, Russia, MS Biology, 1997
  • Russian University of People’s Friendship, Moscow, Russia, PhD Physiology, 2003

Honors

  • 2010-2013 NIH Grant (R03 DC11142-01)
  • 2001 – 2002 CRDF Fellowship (Civilian Research and Development Foundation)
  • 2001 George Soros Foundation Award for Post-Graduate Student
  • 2000 Visiting international post-graduate student, University of Missouri, St. Louis, USA
  • 1999 Travel Fellowship for the 2nd Federation of European Physiological Societies Congress, Prague. June 29 - July 4
  • 1999 Travel Fellowship for Workshop in the Technical University of Denmark under auspices of the Danish School in Nonlinear Science, Denmark

Selected Publications

  1. Yakusheva T, Blazquez P, Angelaki D. (2010) Relationship between complex and simple spike activity in macaque caudal vermis during three-dimensional vestibular stimulation. Journal of Neuroscience. 30(24):8111-26.

  2. Angelaki DE, Yakusheva TA, Green AM, Dickman JD, Blazquez PM. (2010) Computation of egomotion in the macaque cerebellar vermis. Cerebellum ;9(2):174-82. Review.

  3. Sheng Liu, Tatyana Yakusheva, Gregory C. DeAngelis and Dora E. Angelaki (2010) Direction discrimination thresholds of vestibular and cerebellar nuclei neurons. Journal of Neuroscience. 30(2):439-48.

  4. Angelaki D.E., Yakusheva T.A. (2009) How Vestibular Neurons Solve the Tilt/Translation Ambiguity: Comparison of Brainstem, Cerebellum, and Thalamus Annals of the New York Academy of Sciences, Volume 1164 (1): 19-28.

  5. Yakusheva T, Blazquez P, Angelaki D. (2008) Frequency-selective coding of translation and tilt in macaque cerebellar nodulus and uvula Journal of Neuroscience. 2008 Oct 1;28 (40):9997-10009.

  6. Yakusheva TA, Shaikh AG, Green AM, Blazquez PM, Dickman JD, Angelaki DE (2007) Purkinje cells in posterior cerebellar vermis encode motion in an inertial reference frame. Neuron, 54:973-985.

  7. Neiman AB, Yakusheva TA, Russell DF (2007) Noise-induced transition to bursting in responses of paddlefish electroreceptor afferents. Journal of Neurophysiology, 98:2795-2806.

  8. Neiman AB, Russell DF, Yakusheva TA, DiLullo A, Tass PA (2007) Response clustering in transient stochastic synchronization and desynchronization of coupled neuronal bursters. Physical review. E, Statistical, nonlinear, and soft matter physics 76(2 Pt 1):021908.

  9. Freund JA, Schimansky_Geier L, Beisner B, Neiman A, Russell DF, Yakusheva T Moss F. (2002) Behavioral stochastic resonance: how the noise from a Daphnia swarm enhances individual prey capture by juvenile paddlefish. Journal of Theoretical Biology 214:1 71-83

  10. Freund JA, Kienert J, Schimansky_Geier L, Beisner B, Neiman A, Russell DF, Yakusheva T, Moss F (2001) Behavioral stochastic resonance: How a noisy army betrays its outpost. Physical review. E, Statistical, nonlinear, and soft matter physics 63:3 Pt 1 031910.

  11. Anishchenko VS, Igosheva NB, Pavlov AN, Khovanov A, Yakusheva TA (2001) Comparative analysis of methods for classifying the cardiovascular system's states under stress. Critical Reviews in Biomedical Engineering 29:3 462-81.

  12. Anishchenko T, Igosheva N, Yakusheva T, Glushkovskaya_Semyachkina O, Khokhlova O. (2001) Normalized entropy applied to the analysis of interindividual and gender-related differences in the cardiovascular effects of stress. European Journal of Applied Physiology, 85:3-4 287-98.