The red symbols show diffusion coefficients for the substances listed in the table below according to their formula weight. Where coefficients were measured at other temperatures they have been corrected to 37 degrees, taking into account the combined effects of temperature and the change of viscosity of water. (Hobbie, 1978) The blue line is the relationship determined by Hobbie (1978) which is incorporated into the fluids simulator, whereby D is calculated based on an entered formula weight for a substance.
We will add diffusion coefficients for commonly-used solutes as they become available. If you find values elsewhere that would be appropriate to add to this listing then please send them by e-mail to salta@msnotes.wustl.edu
| Chemical | Diffusion Coefficients x 10-5 cm2/s OR x 10-9 m2/s all corrected to 37 degrees C |
Formula Weight (Da) |
Comment |
| Alpha napthalene sulfonate |
0.76 | 207.3 | Nicolson & Phillips (1981) J. Physiol 321, 225 |
| Arsenic hexafluoride (AsF6) |
1.4 | 188.8 | Nicolson & Phillips (1981) J. Physiol 321, 225 |
| CaCl2 | 1.49 | 110.8 | Handbook of Chemistry & Physics, CRC press |
| Citric acid | 0.885 | 192.1 | Handbook of Chemistry & Physics, CRC press |
| Dexamethasone | 0.770 | 392.5 | Based on FW |
| Fluorescein | 0.7827 | 376 | Based on FW |
| Glucose | 0.98 | 180 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Glucose | 0.9 | 180 | Handbook of Chemistry & Physics, CRC press |
| Glucose (average) | 0.94 | ||
| Glycine | 1.43 | 132.1 | Handbook of Chemistry & Physics, CRC press |
| Haemoglobin | 0.1 | 64K | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Inulin | 0.28 | 7K | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| KCl | 2.47 | 74.5 | Handbook of Chemistry & Physics, CRC press |
| LiCl | 1.7 | 42.4 | Handbook of Chemistry & Physics, CRC press |
| Mannitol | 0.9 | 182.2 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Mannitol | 0.91 | 182.2 | Handbook of Chemistry & Physics, CRC press |
| Mannitol (average) | 0.905 | ||
| Methylprednisolone | 0.784 | 374.5 | Based on FW |
| NaCl | 1.99 | 58.4 | Handbook of Chemistry & Physics, CRC press |
| Oxygen | 1.5 | 32 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Prednisolone | 0.795 | 360.5 | Based on FW |
| Raffinose | 0.59 | 595 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Raffinose | 0.58 | 595 | Handbook of Chemistry & Physics, CRC press |
| Raffinose (average) | 0.585 | ||
| Ribonuclease | 0.18 | 14K | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Sucrose | 0.71 | 342 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |
| Sucrose | 0.7 | 342 | Handbook of Chemistry & Physics, CRC press |
| Sucrose (average) | 0.705 | ||
| Tetraethyl- ammonium (TEA) |
1.32 | 130.2 | Salt, unpublished measurements, n=3 |
| TEA | 0.79 | 130.2 | Nicolson & Phillips (1981) J. Physiol 321, 225 |
| TEA (average) | 1.055 | ||
| Trimethylphenyl- ammonium (TMPA) |
1.018 | 135.6 | Salt, unpublished measurements, n=3 |
| Tetramethyl- ammonium (TMA) |
1.76 | 74.1 | Salt, unpublished measurements, n=3 |
| TMA | 1.11 | Nicolson & Phillips (1981) J. Physiol 321, 225 | |
| TMA (average) | 1.435 | ||
| Urea | 1.67 | 61 | Hobbie (1978) Intermediate Physics for Advance Biology, Wiley press |