Select Publications

Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset.

Sheets L, He XJ, Olt J, Schreck M, Petralia RS, Wang YX, Zhang Q, Beirl A, Nicolson T, Marcotti W, Trapani JG, Kindt KS. Journal of Neuroscience.

Ca2+-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse.

Sebe JY, Cho S, Sheets L, Rutherford MA, von Gersdorff H, Raible DW. Journal of Neuroscience. 2017 Jun 21;37(25):6162-6175. doi: 10.1523/JNEUROSCI.3644-16.2017.

Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation. Sheets L. Sci Rep. 2017 Jan 23. 7:41102. doi: 10.1038/srep41102. 

Synaptic ribbons require ribeye for electron density, proper synaptic localization, and recruitment of calcium channels. Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D. Cell Rep. 2016 Jun 21. 15(12):2784–95. doi: 10.1016/j.celrep.2016.05.045. 

Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons. Sheets L, Hagen MW, Nicolson T. PLoS One. 2014 Sep 10. 9(9):e107256. doi: 10.1371/journal.pone.0107256.

Presynaptic CaV1.3 channels regulate synaptic ribbon size and are required for synaptic maintenance in sensory hair cells. Sheets L, Kindt KS, Nicolson T. Journal of Neuroscience. 2012 Nov 28. 32(48):17211–17224

Ribeye is required for presynaptic CaV1.3a channel localization and afferent innervation of sensory hair cells. Sheets L, Trapani JG, Mo W, Obholzer N, Nicolson T. Development. 2011 Apr. 138(7):1309–19.

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