Molly E. Heft Neal, MD

Fellow in advanced head and neck surgical oncology and microvascular reconstruction
Otolaryngology—Head & Neck Surgery

Specialties

Dr. Heft Neal is a current fellow in advanced head and neck surgical oncology and microvascular reconstruction. Her clinical interests include head and neck benign and malignant lesions, thyroid and parathyroid tumors, sinonasal benign and malignant tumors, and reconstruction of head and neck defects.

Education

Undergraduate: BA, Biology – Stanford University, Palo Alto, California (2011)

Medical Degree: University of Pittsburgh School of Medicine (2016)

Residency: Otolaryngology – University of Michigan, Ann Arbor (2022)

Locations

Dr. Heft Neal sees patients at:

Leadership Roles & Honors

  • Rontal Award for Best Presentation at Annual Krause Lectureship, University of Michigan Department of Otolaryngology Head and Neck Surgery (2022)
  • Merle Lawrence, Ph.D. Research Award, University of Michigan Department of Otolaryngology Head and Neck Surgery (2021, 2022)
  • Travel Grant 2022 Multidisciplinary Head and Neck Cancers Symposium, Phoenix, AZ (2021)
  • John L. Kemink, MD Research Award, University of Michigan Department of Otolaryngology Head and Neck Surgery (2019)
  • Graduated Cum Laude, University of Pittsburgh School of Medicine, Pittsburgh, PA (2016)

Publications

  1. Heft Neal ME, Bhangale AD, Birkeland AC, McHugh JB, Shuman AG, Rosko AJ, Swiecicki PL, Spector ME, Brenner JC. Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. Cancers (Basel). 2020 Oct 22;12(11):3081. doi: 10.3390/cancers12113081. PMID: 33105726; PMCID: PMC7690434.
  2. Heft Neal ME, Smith DJ, Birkeland AC, Haring CT, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, McLaen SA, Rosko AJ, Mierzwa ML, Shah J, Schonewolf, Swiecicki PL, Worden FP, Wolf GT, Bradford CR, Prince MEP, Brenner JC, Spector ME. Tumor-Infiltrating Lymphocytesin Patients With Advanced LaryngealCancer Undergoing Bioselection. Otolaryngology–Head and Neck Surgery. 2021. DOI: 10.1177/01945998211013765http://otojournal.org
  3. Heft Neal ME, Andrew B, Apurva B, Jingyi Z, Aditi K, Susan F, Brittany J, Megan L, Lisa P, Hui J, Jonathan M, Lawence M, Erin M, Brenner J. Genetic Analysis of Sinonasal Undifferentiated Carcinoma Discovers Recurrent SWI/SNF Alterations and a novel PGAP3-SRPK1 Fusion Gene. BMC Cancer. 2021. doi: 10.21203/rs.3.rs-115402/v1.
  4. Heft Neal ME, Gao RW, Brennan JR, Haring CT, Chinn SB, Shuman AG, Casper KA, Malloy KM, Stucken CL, Mclean SA, Chad Brenner J, Lyden T, Blakely A, Mierzwa ML, Shah J, Schonewolf C, Swiecicki PL, Worden FP, Wolf GT, Bradford CR, Prince MEP, Rosko AJ, Spector ME. Functional outcomes and tracheostomy dependence following salvage oropharyngeal surgery. Oral Oncol. 2020 Oct 8:105034. doi: 10.1016/j.oraloncology.2020.105034. Epub ahead of print. PMID: 33041214.
  5. Heft Neal ME, Spielbauer KK, Spector ME. Time to Surgery and Survival in Head and Neck Cancer. Ann Surg Oncol. 2020 Nov 9:1–2. doi: 10.1245/s10434-020-09336-2. Epub ahead of print. PMID: 33165724; PMCID: PMC7651805.
  6. Heft Neal ME, Michmerhuizen NL, Kovatch KJ, Owen JHJ, Zhai J, Jiang H, McKean EL, Prince MEP, Brenner JC. (2020). Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma. J Neurol Surg B 2020;00:1–43.
  7. Heft Neal ME, Brennan J, Brenner JCet al. Predictors and Prevalence of Nodal Disease in Salvage Oropharyngectomy. Annals of surgical oncology 2020; 27:451-457.
  8. Heft Neal ME, Brennan J, Haring CTet al. Predictors of survival in patients undergoing oropharyngeal surgery for cancer recurrence after radiation therapy. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2020; 277:2085-2093.
  9. Heft Neal ME, Haring CT, Mann JE, Brenner JC, Spector ME, Swiecicki PL. Novel Immunotherapeutic Approaches in Head and Neck Cancer. Journal of cancer metastasis and treatment 2019; 5.
  10. Heft Neal ME, Rowan NR, Willson TJ, Wang EW, Lee SE. A Case Report and Systematic Review of Eosinophilic Angiocentric Fibrosis of the Paranasal Sinuses. The Annals of otology, rhinology, and laryngology 2017; 126:415-423.
  11. Heft Neal ME, Spector ME. ASO Author Reflections: Nodal Disease in Recurrent Oropharynx. Annals of surgical oncology 2020; 27:458-459.
  12. Heft Neal ME, Gensterblum-Miller E, Bhangale AD, Kulkarni A, Zhai J, Smith J, Brummel C, Foltin SK, Thomas D, Jiang H, McHugh JB, Brenner JC. Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma. Oral Oncology.
  13. Heft Neal ME, Brenner JC, Prince MEP, Chinn SB. “Head and Neck Cancer Stem Cells and the Tumor Microenvironment: The role of neighboring cells in maintenance of a CSC niche.” Frontiers Cell and Developmental Biology
  14. Cao Y, Catherine C, Brummel C, Bhambhani C, Aryal M, Lee C, Heft Neal ME, Bhangale A, Gu W, Casper K, Malloy K, Sun Y, Shuman A, Prince M, Spector M, Chinn S, Shah J, Schonewolf C, McHugh J, Mills R, Tewari M, Worden F, Swiecicki p, Mierzwa M, Brenner JC. Early Two Week Circulating Tumor HPV DNA and Imaging Biomarkers Predict Treatment Response in p16+ Oropharyngeal Squamous Cell Carcinoma. Clinical Cancer Research. 2021
  15. Prince, ADP, Broderick, MT, Heft Neal, ME, Spector, ME. J. F. o. O., & Medicine, M. (2020). Head and neck reconstruction in the vessel depleted neck. 2020, 2.
  16. Michmerhuizen NL, Owen JH, Heft Neal ME et al. Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy. Journal of neuro-oncology 2020; 147:25-35.
  17. Rowan NR, Stapleton AL, Heft-Neal ME, Gardner PA, Snyderman CH. The Natural Growth Rate of Residual Juvenile Angiofibroma. Journal of neurological surgery Part B, Skull base 2018; 79:257-261.
  18. Rowan NR, Zwagerman NT, Heft-Neal ME, Gardner PA, Snyderman CH. Juvenile Nasal Angiofibromas: A Comparison of Modern Staging Systems in an Endoscopic Era. Journal of neurological surgery Part B, Skull base 2017; 78:63-67.
  19. Xiw Y, Heft Neal ME, Rudy SF, Grunebaum LD, Shaye DA, Brenner MJ. Lip and Perioral Trauma: Principles of Aesthetic and Functional Reconstruction. Facial Plastic Surgery. 2020.
  20. Farlow JL, Devare J, Ellsperman SE, Haring CT, Heft Neal ME, Pleasant T, Spielbauer KK, Sylvester MJ, Xie Y, Marchiano EJ. Virtual Resident Mentorship Groups for Fourth Year Medical Students Applying into Otolaryngology-Head and Neck Surgery. Ann Otol Rhinol Laryngol. 2021 May 12:34894211015740. doi: 10.1177/00034894211015740. Epub ahead of print. PMID: 33978510.
  21. Haring CT,  Brummel C, Bhambhani C, Jewell B; Heft Neal ME; Bhangale A, Tewari M, Casper K, Malloy K, McLean S, Shuman A, Stucken C, Rosko A, Prince M, Bradford CR, Eisbruch A, Mierzwa M, Worden F; Swiecicki PL, Spector ME, Brenner JC. Implementation of Human Papillomavirus Circulating Tumor DNA to Identify Recurrence during Treatment De-Escalation. Oral Oncology 2021.
  22. Haring CT, Farlow J, Leginza M, Blakely A, Lyden T, Hoesli R, Heft Neal ME, Vance K, Hogikyan ND, Morrison R, Casper K. Effect of Augmentative Technology on Communication and Quality of Life After Tracheostomy or Total Laryngectomy Otolaryngology- Head and Neck Surgery. 2021
  23. Haring CT, Bhambhani C, Brummel C, Jewell B, Bellile E, Heft Neal ME, Sandford E, Spengler RM, Bhangale A, Spector ME, McHugh J, Prince ME, Mierzwa M, Worden FP, Tewari M, Swiecicki PL, Brenner JC. Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma. Oncotarget. 2021 Jun 22;12(13):1214-1229. doi: 10.18632/oncotarget.27992. PMID: 34194620; PMCID: PMC8238244.