Hearing researchers from WashU Medicine Otolaryngology contributed a broad spectrum of scientific findings at the annual Midwinter Meeting of the Association for Research in Otolaryngology, held February 7-11 in San Juan, Puerto Rico.
The meeting is the largest assembly of hearing scientists in the world and features basic and applied science related to hearing, deafness and balance. The number of scientific contributions by WashU Medicine researchers is larger than it has been in recent years, signifying the growth of the institution’s presence on the national stage.
This was evident to Assistant Professor of Otolaryngology Jinkyung Kim, PhD, one of the newer members of the research team.
“I’ve always known that the research from our senior faculty here is outstanding, but it was especially rewarding to see how widely their efforts are recognized and valued by the field,” she said. “It was quite special to see the work of Drs. Warchol, Ohlemiller and Hirose highlighted. I’m incredibly proud of our group and hope to continue this strong tradition of excellence as part of the WashU Medicine community.”
The meeting is always a valuable experience for trainees as well, a number of which accompanied their mentors to San Juan to showcase their own work.
“ARO was a wonderful opportunity to quickly evaluate the current state of research in our field and obtain valuable feedback on our work,” said Otolaryngology resident Prith Roychowdhury, MD. “I was able to chat with postdocs, residents, and investigators from all over the world about their work and make connections that I otherwise would not have been able to make!”
For Associate Professor of Otolaryngology Mark Rutherford, PhD, San Juan itself offered a unique and timely experience.
“Being in Puerto Rico during the Superbowl was quite an experience,” he said. “Observing the locals enjoying the Super Bowl half-time show was indeed a cultural phenomenon since featured half time performer Bad Bunny is Puerto Rican.”
WashU Medicine Otolaryngology scientific contributions
Evaluating AMPA-Type Glutamate Receptor Saturation at Inner Hair Cell Ribbon Synapses With Glutamate Uncaging and Competitive Inhibition
Walen Gribaudo, Mona Jawad, James Huettner, Mark A. Rutherford, Juan Goutman
Immune Modulation of Zfp719 Dependent Hearing Loss
Tingfang Chen, Sixing Chen, Staci Rakowiecki, Sophie Shapiro, Said Ibrahim, Robert K. Hu, Pablo Gonzalez Camara, Kevin Ohlemiller, Mark Rutherford, Todd Macfarlan, Douglas Epstein*
Using Simulations and Non-Stationary Fluctuation Analysis of Synaptic Currents to Uncover the Properties of Cochlear AMPA-Type Glutamate Receptors: Ca2+ Permeable and Impermeable
Mona Jawad, Mark Rutherford, Juan Goutman, James Huettner, Walen Gribaudo
Absence of the Ampa Receptor Auxiliary Subunit Tarp-Gamma 2 (Stargazin) Leads to Cochlear Synaptopathy and Progressive Hearing Loss in Female Mice
Mark Rutherford, Zhijun Shen, Maolei Xiao, Mona Jawad, Han Van, Yi-Zhi Wang, Jeffrey Savas, Maria Rubio, Terunaga Nakagawa
Evaluating Calcium Dependence of Vesicle Replenishment at Inner Hair Cell Ribbon Synapses
Camila Catalano Di Meo, Walen Gribaudo, Lucia Agüero, Mark Rutherford, Juan Goutman
Investigating the Mechanisms of Hearing Loss in FSHD Using a Transgenic DUX4 Mouse Model
Eleanor Gilstrap, Zhijun Shen, Maolei Xiao, Chun Guo, Darko Bosnakovski, Michael Kyba, Mark A. Rutherford, Renatta Knox
Cross-Species Insights Into Mitochondrial Mechanisms of Delayed Hearing Loss Following Cisplatin Chemotherapy
Neva Bergemann, Elayna Malak, Mona Jawad, Josef Trapani, Mark A. Rutherford, Lavinia Sheets
Persistent Remodeling of Hair Cell Mitochondrial Networks in Response to Low Dose Cisplatin Exposure
Elayna Malak, Josef Trapani, Lavinia Sheets
Clustering Analysis Reveals Distinct Macrophage Phenotypes Following Excitotoxic Injury in the Zebrafish Lateral Line
Prithwijit Roychowdhury, Mark Warchol, Lavinia Sheets
Sound Encoding Properties of Inner Hair Cells in the Living Mouse Cochlea
Mark Presker, Siyang Lin, Gerardo Molina, Kevin Ohlemiller, Edward Han, Jinkyung Kim
A Tumor-Bearing Mouse Model for Studying Cisplatin-Induced Hearing Loss
Cathy Yea Won Sung, John Lee, Mark Warchol, Lisa Cunningham
Reduced or absent Pou4f3 Expression Impairs Utricular Development via Direct Effects on Hair Cells and Non-Cell Autonomous Effects on Supporting Cells
Beatrice Mao, Vikrant Borse, Mark Warchol, Matthew Kelley
Single-Nucleus RNA-Seq Profiling of Cisplatin-Induced Hearing Loss
Amanda Bonczkowski, Franz Gareza, Erica Sadler, Katharine Fernandez, Rafal Olszewski, Michael Hoa, Tessa Sanders, Matthew Kelley, Mark Warchol, Ran Elkon, Ronna Hertzano, Cathy Yea Won Sung, Lisa Cunningham
Single-Cell Transcriptomics Reveals Alterations in the Cochlear Immune Landscape at Hearing Onset in a Murine Model of Cmv-Related Congenital Hearing Loss
Khai Nguyen, Daniel R. Romano, Song-Zhe Li, Keiko Hirose
Single Nucleus RNA-Seq Defines the Cochlear Interferon Response in a Mouse Model of Congenital CMV Infection
Daniel Romano, Song-Zhe Li, Khai Nguyen, Sidharth Puram, William Britt, Keiko Hirose