Cochlear Fluids Research Laboratory

Alec N. Salt, Ph.D.

Department of Otolaryngology
Washington University School of Medicine
St. Louis, Missouri, 63110, USA



The Cochlear Fluids

The cochlea is the portion of the inner ear that is responsible for hearing. This picture shows a cochlea in which the fluid spaces were filled with colored latex and then the bony walls were dissected away. We used orange latex to fill the perilymphatic spaces, and dark blue to fill the endolymphatic space. The spiral, snail-like arrangement of the cochlear fluid spaces is clearly seen.


  A Pictorial Guide to the Inner Ear

  "Fluid in Your Ears"
  Anatomy of the Inner Ear
  Cochlear Anatomy
  Cochlear Fluids Composition
  The Endocochlear Potential
  Endolymphatic Hydrops
  Endolymph Flow in the Normal Cochlea

  Publications from our Group

  Complete Publication List - Including many papers available as pdf files

Recent papers - Click on images to view full paper (pdf format)

Publisher Links---> Elsevier: J. Neuroscience Methods ---> Bell Association: The Volta Review

Publisher Links---> The House Institute ---> Elsevier: Drug Discovery Today

  Cochlear Fluids Studies

  Perilymph Sampling from the Cochlear Apex

  Computer Simulations of Drug Movements in Cochlear Fluids

  Introduction to the 1D Fluids Simulator Program
  Downloading, Installation and Operating Instructions
  Download Latest Simulator Program V 1.6i, December 2005(1.7 Mb windows installation file)
Download and installation of this program should be performed with Microsoft Internet Explorer.
  Documentation of Simulator Revisions
  Guidance for setting Simulation Parameters

  Cochlear Distortion Simulator

  Introduction to the Distortion Simulation Program
  Downloading, Installation and Operating Instructions
  Download the Distortion Simulation Program V 1.1, October, 2003 (2.9 Mb Windows installation file)
Download and installation of this program should be performed with Microsoft Internet Explorer.

  Cochlear Fluid Parameters Database

  Dimensions of Inner Ear Fluid Spaces
  Composition of Inner Ear Fluids
  Resting Potentials of Inner Ear Fluid Spaces
  Longitudinal Flow Rate of Cochlear Fluids
  Diffusion Coefficients for Various Solutes
  Clearance Characteristics for Various Solutes
  Placement locations of electrodes

  3-D Imaging of the Ear with High-Resolution MR

  Introduction and Personnel Involved
  High-resolution Magnetic Resonance Microscopy (MRM) Technique
  Cochlear Fluid Volumes for the Guinea Pig
  Cochlear Fluid Volumes for the Human
  Cochlear Fluid Volumes for the Gerbil
  Cochlear Fluid Volumes for the Bat
  Cochlear Fluid Volumes for the Rat
  Cochlear Fluid Volumes for the Mouse
  Relationship of the Round Window to Scala Tympani
  MR Imaging of the Endolymphatic Sac

  Department of Otolaryngology

  The Meniere's Page

  Radio Controlled Model Airplanes

  The Radio Controlled Airplane Fleet
  St. Louis Radio Control Flying Association

  Alec Salt received the 1999 Guyot prize for research     

 


Quotes that I like

"A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that are familiar with it."
Max Planck

"Fear not the path of truth for the lack of people walking on it."
Robert F Kennedy


Comments are welcome at salta@wustl.edu.

Web page established March 6, 1995
Pages last updated February 2006