Basic scientists from the Department of Otolaryngology at Washington University assembled in Anaheim, Calif., for the annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO), Feb. 3-7.
The meeting is the largest gathering of hearing and balance scientists in the world. Efforts to advance our understanding of hearing and the disorders that affect hearing were on full display. Contributions from WashU scientists included podium and poster presentations, as well as serving as panelists and moderators for special interest sessions.
One highlight of the meeting was the annual Presidential Symposium, which this year featured results from first-ever gene therapy clinical trials to restore hearing in patients congenitally deaf due to otoferlin mutations, a protein necessary for neurotransmitter release from sensory hair cells.
“The Presidential Symposium and other sessions underscore the real importance of collaboration between clinical and basic scientists,” said Associate Professor of Otolaryngology Mark Rutherford, PhD.
Presentations by WashU scientists
Probing Ampa Receptors Activity at Ribbon Synapses in the Mammalian Cochlea by Glutamate Uncaging
Juan Goutman, Mona Jawad, James Huettner, Mark Rutherford
Evaluation of Lhfpl5b Loss-Of-Function on Lateral Line Mediated Behavior, Hair Cell Synapse Morphology, Mitochondrial Homeostasis, and Vulnerability to “Noise” Damage
Keziah-Khue Nguyen, Melanie Holmgren, Lavinia Sheets
Kif1aa-Based Transport and Microtubules Maintains Synaptic Vesicle Populations in Hair Cells
Sandeep David, Katherine Pinter, Keziah-Khue Nguyen, Lavinia Sheets, Katie Kindt
Assessing Factors Influencing the Efficiency of Drug Delivery Via the Semicircular Canal
Jinkyung Kim, Jesus Moldanado, Samantha Zenteno, Anthony Ricci
Developmental Impact on Aav-Dj-Gfp Expression Profile
Sriram Hemachandran, Jinkyung Kim, Hayden Reynso, Evi Scheinbinger, Samantha Zenteno, Anthony Ricci
Macrophage Ablation Protects Against Cisplatin-induced Hearing Loss without affecting the Tumor Efficacy of Cisplatin in Mice
Cathy Yea Won Sung, Bryce Hambach, Haley Ogbemudia, Katharine Fernandez, Mark Warchol, Lisa Cunningham
Regulators of Phagocytosis in the Vestibular Maculae of Mice
Mark Warchol
Bulk RNA-Sequencing Reveals the Spatial-Temporal Transcriptional Dynamics of Hearing Loss in a Mouse Model of Congenital CMV Infection
Daniel Romano, Song-Zhe Li, Alexander Larson, William Britt, Keiko Hirose
Contribution of Macrophages to Neural Survival and Intracochlear Tissue Remodeling Responses following Cochlear Implantation
Muhammad Rahman, Brian Mostaert, Bryce Hunger, Utsow Saha, Alexander Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon Kirk, Keiko Hirose, Marlan Hansen
Dexamethasone-Eluting Cochlear Implants Reduce Intracochlear Foreign Body Response and Electrical Impedance for Extended Period following Surgery in a Murine Model
Muhammad Rahman, Brian Mostaert, Peter Eckard, Bryce Hunger, Alexander Claussen, Ibrahim Razu, Cristina Garcia, Shakila Fatima, Nashwaan Khan, Douglas Bennion, Jonathon Kirk, Keiko Hirose, Marlan R. Hansen
Dexamethasone-Eluting Cochlear Implants Reduce Intracochlear Foreign Body Response Compared to Perioperative Topical Dexamethasone Treatment following Surgery in a Murine Model
Peter Eckard, Muhammad Rahman, Brian Mostaert, Bryce Hunger, Alexander Claussen, Ibrahim Razu, Cristina Garcia, Shakila Mahmuda Fatima, Nashwaan Khan, Douglas Bennion, Jonathon Kirk, Keiko Hirose, Marlan Hansen
Additional service contributions
- Mark Warchol, PhD, served as a panelist for a special session on, “Navigating the grant landscape”.
- Junkyung Kim, PhD, served as a moderator of a podium session on, “Inner ear: ototoxicity and otoprotection”.
- Mark Rutherford, PhD, has been elected to the ARO Nominating Committee.