Keiko Hirose, MD

Keiko Hirose, MD

Professor of Otolaryngology—Head & Neck Surgery

Castle Connolly Top Doctor

Patients seen at

St. Louis Children’s Hospital 
One Children’s Place
Third Floor
St. Louis, MO 63110

Children’s Specialty Care Center
13001 North Outer Forty
Town & Country, MO 63017
Floor 2, Suite D

Mailing address

Washington University School of Medicine
Department of Otolaryngology-Head and Neck Surgery
660 S. Euclid Ave.-Campus Box 8115
St. Louis, MO 63110

Clinical interests

Pediatric hearing loss, cochlear implantation, chronic ear surgery, cholesteatoma, conductive hearing loss, aural atresia, BAHA, ear infections, speech disorders, velopharyngeal insufficiency, cleft palate, craniofacial disorders.

View clinical profile »


  • B.A., Columbia College, Columbia University, New York, 1989
  • M.D., Harvard Medical School, Boston, MA 1993
  • Internship, University of Washington Medical Center, Seattle, WA 1994
  • Residency, University of Washington Medical Center, Seattle, WA 1999
  • Fellowship, Children’s Hospital of Boston, Boston, MA 2000

Licensure and board certification

  • Otolaryngology-Certified


  • Best Doctors in America, 2006-2019
  • St. Louis Magazine, 10 Influential St. Louis Doctors
  • George Adams Young Faculty Triologic Society Award, 2007
  • Resident Travel Award, Combined Otolaryngology Spring Meeting, 1999
  • Resident Travel Award, Western Sectional Meeting of the Triologic Society, 1998 Best Doctors in America, 2006, 2007
  • Cleveland Top Doctors, 2006, 2007

Selected publications

  1. Hirose K, Li SZ, Ohlemiller KK, Ransohoff RM. Systemic lipopolysaccharide induces cochlear inflammation and exacerbates the synergistic ototoxicity of kanamycin and furosemide. J Assoc Res Otolaryngol 2014;15(4):555-70. doi: 10.1007/s10162-014-0458-8. PMCID: PMC4141430. Impact Factor 2.55.
  2. Hirose K, Hartsock JJ, Johnson S, Santi P, Salt AN. Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph. J Assoc Res Otolaryngol 2014;15(5):707-19. doi: 10.1007/s10162-014-0476-6. PMCID: PMC4164684. Impact Factor 2.55.
  3. Kaur T, Hirose K, Rubel EW, Warchol ME. Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle. Front Cell Neurosci 2015;9:150. doi: 10.3389/fncel.2015.00150. eCollection 2015. PMCID: PMC4406144. Impact Factor 4.29.
  4. Kaur T, Zamani D, Tong L, Rubel EW, Ohlemiller KK, Hirose K, Warchol ME. Fractalkine signaling regulates macrophage recruitment into the cochlea and promotes the survival of spiral ganglion neurons after selective hair cell lesion. J Neurosci 2015;35(45):15050-61. doi: 10.1523/JNEUROSCI.2325-15.2015. PMCID: PMC4642237. Impact Factor 6.34.
  5. Wineland A, Menezes MD, Shimony JS, Shinawi MS, Hullar TE, Hirose K*. Prevalence of Semicircular Canal Hypoplasia in Patients With CHARGE Syndrome: 3C Syndrome. JAMA Otolaryngol Head Neck Surg. 2016 Nov 10. doi: 10.1001/jamaoto.2016.3175. PMID: 27832265. 
  6. Shinawi M and Hirose K. Response to letter to the Editor: Prevalence of Semicircular Canal Hypoplasia in Patients with CHARGE Syndrome: 3C Syndrome. JAMA Otolaryngol Head Neck Surg. 2017 Feb 23. doi: 10.1001/jamaoto.2016.4765. PMID: 28241177.
  7. Vila PM, Ghogomu NT, Odom-John AR, Hullar TE, Hirose K*. Infectious complications of pediatric cochlear implants are highly influenced by otitis media. Int J Pediatr Otorhinolaryngol. Published online March 12, 2017. doi:10.1016/j.ijporl.2017.02.026. PMID: 28483256.
  8. Lichtenhan J, Hirose K, Buchman C, Duncan RK, Salt AN. Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements. PLoS One. 2017 Apr 6. doi: 10.1371/journal.pone.0175236. PMID: 28384320. 
  9. Hirose K, Rutherford M, Warchol M. Two cell populations participate in clearance of injured hair cells from the sensory epithelia of the inner ear. 2017 May 16. doi: 10.1016/j.heares.2017.04.006. PMID: 28526177.
  10. Gross JH, Bertrand M, Hirose, K. Benign Rolandic epilepsy presenting like paradoxical vocal fold motion. Int J Pediatr Otorhinolaryngol. 2017 Sept 22. doi: 10.1016/j.ijporl.2017.09.021. PMID: 29106865
  11. Salt A, Hirose, K. Communication pathways to and from the inner ear and their contributions to drug delivery. Her res. Hear Res. 2017 Dec 19. pii: S0378-5955(17)30457-4. doi: 10.1016/j.heares.2017.12.010.

Invited publications

  1. Rizzi M and Hirose K. Aminoglycoside Ototoxicity. In: Current opinions in Otolaryngology and Head and Neck Surgery. 2007;15(5):352-257.
  2. Hirose K. Hearing loss and diabetes: you might not know what you’re missing. Ann Intern Med. 2008;149(1):54-5. PMID: 18559823. Comment on: Bainbridge KE, Hoffman JH, Cowie CC. Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004. 2008;149(1):1-10. Impact factor: 17.81.

Books, chapters published

  1. Kenna MA and Hirose K. Embryology and developmental anatomy of the ear. In: Bluestone, C.D., Stool, S.E., Alper C.M., et al., eds. Pediatric Otolaryngology. 4th ed. Philadelphia: Saunders. 2003.
  2. Sautter N, Hirose K. Otitis media. In: Hughes GB and Pensak ML, eds. Clinic Otology, 3rd ed. Thieme: New York, Stuttgart. 2007:223-35.
  3. Jensen D, Hirose K. Otitis media. In: Chou DI and Pensak ML, eds. Clinic Otology, 4th ed. Thieme: New York, NY. 2011:18.
  4. Page N, Hirose K. Embryology and developmental anatomy of the ear. In: Bluestone CD, Simons JP, Healy GB, et al., eds. Pediatric Otolaryngology, 5th ed. PMPH: Shelton, CT. 2014:20.

View additional publications on PubMed »