Puram Lab Publications

Basic and Translational Research Articles and Reviews:

  1. Puram SV†, Parikh AS, Tirosh I†. “Single cell RNA-sequencing in head and neck cancer highlight a role for a partial epithelial-to-mesenchymal transition,” Molecular and Cellular Oncology (2018). Epub.
  2. Puram SV*, Tirosh I*, Parikh A*, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CC, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE. “Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer,” Cell 171(7): 1611-1624 (2017). PMID: 29198524
  3. Jahani-Asl A, Yin H, Soleimani VD, Takrima H, Luchman AH, Chang NC, Sincennes MC, Puram SV, Ligon KL, Weiss S, Rudnicki MA, Bonni A. “Control of glioblastoma tumorigenesis by feed-forward cytokine signaling,” Nature Neuroscience 19(6): 798-806 (2016). PMID: 27110918.
  4. Puram SV, Rocco JW. “Molecular biology of head and neck cancer,” Hematology Oncology Clinics of North America 29(6): 971-992 (2015). PMID: 26568543.
  5. Valnegri P*, Puram SV*, Bonni A. “Regulation of dendrite morphogenesis by extrinsic cues,” Trends in Neuroscience 38(7): 439-447 (2015). PMID: 26100142.
  6. Puram SV*, Kim AH*, Park HY, Bonni A. “The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain,” Cell Reports 4(1): 19-30 (2013). PMID: 23831032.
  7. Puram SV, Kim AH, Bonni A. “Cell-intrinsic drivers of dendrite morphogenesis,” Development 140(23): 4657-4671 (2013). PMID: 24255095.
  8. Puram SV, Yeung CM, Asl-Jahani A, Lin C, Jackson-Grusby L, Bonni A. “STAT3-iNOS signaling drives astrocyte proliferation and transformation,” Journal of Neuroscience 32(23): 7806-7818 (2012). PMID: 22674257.
  9. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A. “A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain,” Genes and Development 25(24): 2659-2673 (2011). PMID: 22135323.
  10. Puram SV, Kim AH, Ikeuchi Y, Riccio A, Wilson-Grady JT, Gygi SP, Bonni A. “A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain,” Nature Neuroscience 14(8): 973-983 (2011). PMID: 21725312.
  11. Puram SV, Bonni A. “Novel functions for the anaphase-promoting complex in neurobiology,” Seminars in Cell and Developmental Biology 22(6): 5865-94 (2011). PMID: 21439392.
  12. Puram SV, Kim AH, Bonni A. “An old dog learns new tricks: A novel function for Cdc20-APC in dendrite morphogenesis in neurons,” Cell Cycle 9(3): 482-485 (2010). PMID: 20195072.
  13. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keogh S, Wong M, Rowitch D, Bonni A. “A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in post-mitotic neurons,” Cell 136(2): 322-336 (2009). PMID: 19167333.
  14. de la Iglesia N, Puram SV, Bonni A. “STAT3 regulation of glioblastoma pathogenesis,” Current Molecular Medicine 9(5): 580-590 (2009). PMID: 19601808.
  15. de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. “Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway,” Genes and Development 22(4): 449-462 (2008). PMID: 18258752.
  16. Choleris E, Little SR, Mong JA, Puram SV, Langer R, Pfaff DW. “Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice,” Proceedings of the National Academy of Sciences 104(11): 4670-4675 (2007). PMID: 17360582.
  17. Little SR, Lynn DM, Puram SV, Langer R. “Formulation and characterization of Poly-Beta amino ester microspheres,” Journal of Controlled Release 107(3): 449-462 (2005). PMID: 16112767.
  18. Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. “Poly-Beta amino ester-containing microparticles enhance the activity of non-viral genetic vaccines,” Proceedings of the National Academy of Sciences (PNAS) 101(26): 9534-9539 (2004). PMID: 15210954.

Clinical Research Articles:

  1. Holbrook EH*, Puram SV*, See RB, Tripp AG, Nair DG. “Artificially induced smell through trans-ethmoid electrical stimulation of the olfactory bulb,” International Forum of Allergy and Rhinology (In press).
  2. Yu PK, Rathi VK, Sethi RK, Puram SV, Lin DT, Emerick KS, Durand ML, Deschler DG. “Postoperative care in an intermediate-level medical unit after head and neck microvascular free flap reconstruction,” Laryngoscope Investigative Otolaryngology (In press).
  3. Abt NB*, Puram SV*, Sinha S, Sethi RK, Goyal N, Tjoa T, Yarlagadda B, Emerick KS, Rocco JW, Varvares MA, Lin DT, Deschler DG. “Transfusion in head and neck pedicled flap patients: Practice patterns and a comparative analysis by flap type,” Laryngoscope (2018). PMID: 30247764.
  4. Sethi RK, Panth N, Puram SV, Varvares MA. “Opioid prescription patterns among patients with head and neck cancer,” JAMA Otolaryngology-Head and Neck Surgery 144(4):382-383 (2018). PMID: 29522065.
  5. Abt NB, Sethi RK, Puram SV, Varvares MA. “Preoperative laboratory data predicts complications and surgical site infection in composite head and neck surgical resections,” American Journal of Otolaryngology S0196-0709(17): 31024 (2018). PMID: 29398185.6. Puram SV†, Bhattacharyya N. “Identifying metrics and factors affecting readmission rate following head and neck cancer surgery,” Otolaryngology Head and Neck Surgery 158(5):860-866 (2018). PMID: 29336226.
  6. Rathi VK, Gadkaree SK, Kozin ED, Naunheim MR, Sethi RK, Puram SV, Gray ST. “US Food and Drug Administration Clearance of Moderate-Risk Otolaryngologic Devices via the 510(k) Process, 1997-2016,” Otolaryngology Head and Neck Surgery 157(4): 608-617 (2017). PMID: 28786317.
  7. Barber SR, Kozin ED, Remenschneider AK, Puram SV, Smith M, Cunnane ME, Herrmann BS, Brown MC, Lee DJ. “Auditory brainstem implant array position varies widely among adult and pediatric patients and is associated with perception,” Ear and Hearing 38(6): e343-e351 (2017). PMID: 28700445.
  8. Abt NB, Xie Y, Puram SV, Richmon JD, Varvares MA. “Frailty Index: Intensive care unit complications in head and neck oncologic regional and free flap reconstruction,” Head and Neck 39(8): 1578-1585 (2017). PMID: 28449296.
  9. Puram SV, Chow H, Wu CW, Heaton J, Kamani D, Gorti G, Chiang FY, Dionigi G, Barczynski M, Schneider R, Dralle H, Lorenz K, Randolph GW. “Posterior cricoarytenoid muscle electrophysiologic changes measured with a posterior cricoid electrode are predictive of vocal cord paralysis with recurrent laryngeal nerve compressive injury in a canine model,” Laryngoscope 126(12): 2744-2751 (2016). PMID: 27113438.
  10. Sinha S*, Puram SV*, Sethi RK, Parikh A, Tjoa T, Goyal N, Yarlagadda BB, Varvares MA, Rocco JW, Emerick KS, Lin D, Durand M, Deschler DG. “Perioperative deep vein thrombosis risk stratification: A comparative analysis of free and pedicled flap patients,” Otolaryngology Head and Neck Surgery 156(1): 118-121 (2016). PMID: 276000631.
  11. Puram SV*, Barber SR*, Kozin ED, Shah P, Remenschneider AK, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. “Outcomes following pediatric auditory brainstem implant surgery: Early experiences in a North American center,” Otolaryngology Head and Neck Surgery 155(1): 133-138 (2016). PMID: 27095049.
  12. Puram SV†, Bhattacharyya N. “Quality indicators for head and neck oncologic surgery: Academic versis nonacademic outcomes,” Otolaryngology Head and Neck Surgery 155(5): 733-739 (2016). PMID: 27329425.
  13. Puram SV, Chow H, Wu CW, Heaton J, Kamani D, Gorti G, Chiang FY, Dionigi G, Barczynski M, Schneider R, Dralle H, Lorenz K, Randolph GW. “Vocal cord paralysis predicted by neural monitoring electrophysiologic changes with recurrent laryngeal nerve compressive neuropraxic injury in a canine model,” Head and Neck 38(S1): E1341-E1350 (2016). PMID: 26348472.
  14. Puram SV, Herrmann BS, Barker FG, Lee DJ. “Retrosigmoid craniotomy approach for auditory brainstem implantation: The Massachusetts Eye and Ear-Massachusetts General Hospital experience,” Journal of Neurological Surgery Part B: Skull Base 76(6): 440-450 (2015). PMID: 27054058.
  15. Noij KS, Remenschneider AK, Kozin ED, Puram S, Herrmann B, Cohen M, Cunnane MB, Lee DJ. “Direct parasagittal magnetic resonance imaging of the internal auditory canal to determine cochlear or auditory brainstem implant candidacy in children,” Laryngoscope 125(10): 2382-5 (2015). PMID: 25778542.
  16. Puram SV, Roberts DS, Niesten ME, Dilger AE, Herrmann BS, Lee DJ. “Cochlear implant outcomes in patients with superior canal dehiscence,” Cochlear Implants International 16(4):213-221 (2015). PMID: 24074366.
  17. Puram SV*, Kozin ED*, Sethi RK*, Hight AE, Shrime MG, Gray, ST, Cohen MS, Lee DJ. “Influence of trainee participation on operative times for adult and pediatric cochlear implantation,” Cochlear Implants International 16(3): 175-179 (2015). PMID: 25387322.
  18. Puram SV*, Kozin ED*, Sethi RK*, Lee DJ, Alkire B, Gray ST, Shrime MG, Cohen MS. “Impact of resident surgeons on procedure length based on common pediatric otolaryngology cases,” Laryngoscope 125(4): 991-997 (2015). PMID: 25251257.
  19. Puram SV, Tward AD, Jung D, Dilger AE, Hermann BS, Dumhaime AC, Barker FG, Lee DJ. “Auditory brainstem implantation in infants: Experience with a 16 month old with cochlear and cochlear nerve hypoplasia,” Otology Neurotology 36(4): 618-624 (2015). PMID: 25473959.
  20. Kaplan AB, Kozin ED, Puram SV, Owoc M, Shah P, Hight AE, Remenschneider A, Lee DJ. “Auditory brainstem implant candidacy in the United States in Children 0-17 Years Old,” International Journal of Pediatric Otorhinolaryngology 79(3): 310-315 (2015). PMID: 25577282.
  21. Puram SV, Yarlagadda BB, Sethi RK, Muralidhar V, Chambers KJ, Emerick KS, Rocco JW, Lin DT, Deschler DG. “Transfusion in head and neck free flap patients: Practice patterns and a comparative analysis by flap type,” Otolaryngology Head and Neck Surgery 152(3): 449-457 (2015). PMID: 25628368.